Improved developmental quality in a patient with trisomy 21 following treatment for refractory Lennox-Gastaut syndrome by total corpus callosotomy: a case report

The indications for surgical intervention epilepsy associated with chromosomal abnormalities remain controversial. We report a 13-year-old girl trisomy 21 and refractory epilepsy. patient developed West syndrome at the age of 5 months. seizures were to multiple antiepileptic drugs, adrenocorticotropic hormone therapy, ketogenic diet. Lennox-Gastaut 7 years. Frequent daily including several sound-induced tonic impeded living her caregivers. For alleviation these seizures, underwent total corpus callosotomy 13 disappeared almost completely, state that continued throughout one year follow-up. patient's cognitive development also improved caregivers satisfied outcomes. Appropriate may suppress in patients 21.